Despite the success of Vision-Language Models (VLMs) like CLIP in aligning vision and language, their proficiency in detailed, fine-grained visual comprehension remains a key challenge. We present CLIP-IN, a novel framework that bolsters CLIP's fine-grained perception through two core innovations. Firstly, we leverage instruction-editing datasets, originally designed for image manipulation, as a unique source of hard negative image-text pairs. Coupled with a symmetric hard negative contrastive loss, this enables the model to effectively distinguish subtle visual-semantic differences. Secondly, CLIP-IN incorporates long descriptive captions, utilizing rotary positional encodings to capture rich semantic context often missed by standard CLIP. Our experiments demonstrate that CLIP-IN achieves substantial gains on the MMVP benchmark and various fine-grained visual recognition tasks, without compromising robust zero-shot performance on broader classification and retrieval tasks. Critically, integrating CLIP-IN's visual representations into Multimodal Large Language Models significantly reduces visual hallucinations and enhances reasoning abilities. This work underscores the considerable potential of synergizing targeted, instruction-based contrastive learning with comprehensive descriptive information to elevate the fine-grained understanding of VLMs.